Roxithromycin

Roxithromycin
4.67 ratingsReviews
Generic:
Roxithromycin
Indications:
infections
Analogs:
Azithromycin Clarithromycin Erythromycin Spiramycin Josamycin Amoxicillin Doxycycline Rulide Augmentin Levofloxacin
In stock: 19 packs
AdultsPregnancyAllergiesDiabetesBreastfeedingChildrenDriving

Dosages

Roxithromycin 150 mg

Quantity Price per tablet You save Total price
60 C$1.40 - C$84.14
90 C$1.26 C$12.39 C$113.82
120 C$1.22 C$21.84 C$146.44
180 C$1.16 C$43.96 C$208.46
270 C$1.11 C$78.33 C$300.30
360 C$1.09 C$113.12 C$391.72

Manufacturers

Alphapharm Pty LtdMerckle GmbHSanofi-Aventis AustraliaSanofi-Aventis Deutschland GmbHSanofi-Aventis, S.A.Sanofi S.p.A.Sanofi Winthrop Industrie

Payment & Shipping

Package Example

Your order is carefully packed and ships within 24 hours. Here is what a typical package looks like.

Sized like a regular personal letter (approximately 24x11x0.7 cm), with no indication of what is inside.

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Shipping Times
Shipping MethodEstimated delivery
Express Free for orders over C$420.00Estimated delivery to Canada: 4-7 days
Standard Free for orders over C$280.00Estimated delivery to Canada: 14-21 days
EMSCanada Post
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Discount Coupons

  • Victoria Day - May 18, 2026 8% VICTORIA8
  • Canada Day - July 1, 2026 10% CANADADAY10
  • Labour Day - September 7, 2026 6% LABOUR6
  • Thanksgiving (Canada) - October 12, 2026 9% THANKS9
  • Boxing Day - December 26, 2026 12% BOXING12

FAQ

Take the missed dose when you remember, unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and continue the regular schedule; do not take two doses at once.

A generic Roxithromycin product contains roxithromycin as its active ingredient. The manufacturer, tablet appearance, packaging, and inactive ingredients can differ from a brand-name product, so these details should be checked on the received package.

A different appearance alone does not mean the medicine is incorrect, as manufacturers and packaging may change. Compare the active ingredient, 150 mg strength, film-coated tablet form, manufacturer, package label, lot number, expiry date, and any imprint; do not take the tablets if any of these identifiers appears wrong or the package is damaged.

During pregnancy, Roxithromycin should be used only when a clinician decides that the expected benefit outweighs the potential risk, as human safety data are limited. Roxithromycin passes into breast milk in small amounts and is generally avoided during breastfeeding; a prescriber should consider an alternative or whether breastfeeding should be interrupted.

Description

Note: Images in the description are provided for informational purposes and may differ from the actual appearance of the product. Please refer to the product name, strength, ingredients, and dosage form.

Roxithromycin is a macrolide antibiotic used in some countries to treat bacterial infections caused by susceptible bacteria, most often respiratory tract infections and some skin or soft tissue infections. It is an oral, prescription-only medication; in Canadian clinical practice, antibiotic choice should be guided by a licensed prescriber based on local availability and the specific infection being treated.

Roxithromycin

What it's used for

Roxithromycin may be prescribed for bacterial infections caused by susceptible organisms, including some upper and lower respiratory tract infections and some skin or soft tissue infections. It does not work against viral illnesses such as colds or the flu.

How to take it

In markets where it is approved, roxithromycin is typically taken by mouth once or twice daily, often at least 15 minutes before meals, since food can reduce absorption. Follow your prescriber's directions and finish the full course unless you are told otherwise.

Roxithromycin vs. other antibiotics

Comparison Roxithromycin Amoxicillin Azithromycin Erythromycin
Drug class Macrolide Penicillin (beta-lactam) Macrolide (azalide) Macrolide
Typical role An alternative option in some countries for susceptible respiratory or skin infections A common first-line option for many ENT or respiratory infections, when appropriate Often used for certain respiratory infections and some atypical pathogens, when appropriate An older macrolide; still used, but often limited by GI side effects and interactions
Penicillin allergy May be an alternative for some people with penicillin allergy, depending on clinical judgment Not suitable in true immediate-type penicillin allergy May be an alternative for some people with penicillin allergy, depending on clinical judgment May be an alternative for some people with penicillin allergy, depending on clinical judgment
Food effect Absorption can be reduced by food; often taken before meals Usually can be taken with or without food, depending on the product Depends on the formulation; many can be taken with or without food Depends on the salt or formulation; some are affected by food
Common side effects GI upset (nausea, abdominal pain, diarrhea), headache, rash GI upset, rash; diarrhea can occur GI upset, diarrhea; often less nausea than erythromycin GI upset is common; nausea and abdominal cramps are frequent
QT/arrhythmia risk Macrolide class warning: QT prolongation can occur in rare cases Not a typical QT-prolonging antibiotic Macrolide class warning: QT prolongation can occur in rare cases Macrolide class warning: QT prolongation can occur in rare cases
Drug interaction potential Can interact with some medications (see below); use caution with anticoagulants Fewer CYP-related interactions than macrolides Generally fewer CYP3A interactions than erythromycin or clarithromycin More CYP-related interactions than many alternatives

When doctors usually choose which one

Scenario (simplified) Often considered Notes
A typical bacterial ENT or respiratory infection where a beta-lactam is appropriate Amoxicillin A common first-line choice in many guidelines and markets; this depends on the diagnosis and local resistance patterns.
Suspected atypical respiratory pathogens, or when a macrolide-type option is needed Azithromycin Often preferred within the macrolide class because of convenient dosing and generally fewer CYP3A interactions than erythromycin.
Need for a macrolide alternative where it is available locally Roxithromycin Used in some countries; take local product information into account. In the U.S., it is not approved by the FDA.
A macrolide is needed but newer alternatives are not suitable or available Erythromycin It can be effective in some settings, but GI side effects and interactions can limit its use.
When to be extra cautious with macrolides Roxithromycin / Azithromycin / Erythromycin Use caution with known QT prolongation, electrolyte abnormalities, or other QT-prolonging medications.

How it works

Roxithromycin is a macrolide antibiotic. It binds to the 50S ribosomal subunit and blocks bacterial protein synthesis.

Side effects

Common side effects include nausea, abdominal pain, diarrhea, headache, and skin rash.

Stop taking the medication and get urgent medical care if you develop signs of a serious allergic reaction, such as swelling of the face, lips, or tongue, trouble breathing, severe skin reactions with blistering or peeling, severe or persistent diarrhea, or symptoms of liver injury such as dark urine, yellowing of the skin or eyes, or severe fatigue.

Warnings and precautions

  • Heart rhythm: rare cases of QT prolongation and serious arrhythmias have been reported with macrolides. Use extra caution if you have known QT prolongation, low potassium or magnesium, a slow heart rate, or if you take other QT-prolonging medications.
  • Antibiotic-associated diarrhea: severe diarrhea, including C. difficile colitis, can occur during or after antibiotic treatment.
  • Liver: liver injury has rarely been reported. Use caution in severe hepatic impairment and follow your clinician's advice.
  • Kidney: rare cases of interstitial nephritis have been reported.

Drug interactions

Tell your clinician or pharmacist about all medications and supplements you take. Important interactions may include:

  • Warfarin and other vitamin K antagonists: increased INR and bleeding have been reported; INR monitoring is recommended during combined use.
  • Statins and fibrates: rare cases of muscle toxicity have been reported with interacting combinations; report muscle pain or weakness promptly.
  • Theophylline: exposure may increase slightly; monitoring may be needed in some people.
  • QT-prolonging medications: taking these together can increase the risk of arrhythmias.

Special populations

  • Pregnancy and breastfeeding: use only if prescribed. Small amounts may pass into breast milk; discuss the risks and benefits with a clinician.
  • Hepatic impairment: dose reduction may be recommended in severe hepatic impairment, under clinician guidance.
  • Renal impairment: for short courses, dose adjustment is often not needed; severe impairment should be managed by a clinician.
  • Children: pediatric dosing is based on body weight and should follow local product information and clinician guidance.

Pharmacokinetics

Roxithromycin has an absolute bioavailability of about 50%. Peak concentrations usually occur about 1-2 hours after a dose. Food can reduce absorption. It is highly protein bound and distributes into tissues; small amounts may be found in breast milk. It is eliminated by multiple routes, including fecal and urinary elimination, with a reported half-life of around 12 hours in healthy adults. The half-life may be longer in hepatic or renal impairment.

Off-label / investigational mentions

Some studies have looked at macrolides, including roxithromycin, for conditions such as gingival overgrowth or cardiovascular prevention. These are not standard approved uses.

Storage

Store below 25°C (77°F) in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Medically reviewed by
Donna Brettler
BPharm, MPH - Pharmacologist and medical writer
Updated August 11, 2026

Customer questions

Asked by Meghan, Winnipeg, Canada

I'm in Winnipeg and winter delivery conditions can be unpredictable. Can Roxithromycin 150 mg film-coated tablets normally travel safely by mail?

Answered by Support team

Film-coated tablets can normally be mailed when they are appropriately protected in their packaging. Keep them dry and protected from light, store them below 25°C after arrival, and check the package and tablets for damage or moisture before use.

Asked by Claire, Victoria, Canada

I noticed more hair shedding after starting Roxithromycin. Is hair loss a known side effect of these 150 mg tablets?

Answered by Support team
Medical reviewed by Brian Holtry

Hair loss is not a typical listed adverse effect of Roxithromycin. Diarrhea, nausea, abdominal pain, vomiting, headache, rash, and taste changes are more commonly reported; persistent or substantial hair shedding should be assessed because illness, stress, and other medicines can also contribute.

Product specifications

Active ingredientRoxithromycin
Drug classMacrolide antibiotic
Dosage formFilm-coated tablet
Available strengths150 mg
Route of administrationOral
StorageStore below 25°C in a dry place, protected from moisture and light.
ATC codeJ01FA06

Regulatory information

Authorization StatusRoxithromycin is not authorized for human use in Canada.

More information